DBS is a surgery that helps with movement symptoms of Parkinson’s.

DBS is a procedure that can help some people with Parkinson’s most bothersome movement symptoms… it is not a cure and does not treat non-motor symptoms.

What is DBS?

DBS is a surgical procedure used to treat the often debilitating movement symptoms of Parkinson’s. These include tremor, stiffness, slowed movement, and slowed walking as well as dyskinesia (1). It is important to note that DBS does not cure Parkinson’s, help non-motor symptoms, or stop its progression. DBS’s efficacy, or magnitude of symptom improvements will reduce over time. 

Currently DBS is for people that have had Parkinson’s at least four years and whose motor symptoms cannot be adequately controlled with medications any longer but had responded well earlier. The procedure will never get you back to 100% but will get you to your best ‘on-state’ on medication at the time of the procedure.

Tiny electrodes are surgically implanted into the brain and connected by a wire under the skin to a battery. The pulse generator and electrodes painlessly stimulate the brain in a way that helps to stop many of the symptoms.

Who is best suited to DBS?

DBS is not right for everyone, as many symptoms, such as those impacting speech, swallowing, thinking, or gait (balance and freezing), do not consistently respond well to DBS.

  • Pros: While there may be some scarring, DBS is not felt to damage healthy brain tissue or destroy nerve cells. Instead, the procedure interrupts problematic electrical signals from targeted areas in the brain.
  • Cons: Like any surgery, the procedure does carry risks including side-effects, infection, stroke, bleeding, or seizure.

The most common side-effect of DBS is dysarthria which may result in reduced clarity of speech, slurred or slow speech, making it hard to understand (2). There can also be slight changes in finding the right words to say or personality changes. A small number of people living with Parkinson’s have experienced cognitive decline after DBS surgery. 

DBS can be life-changing for many people with Parkinson’s, but it’s important to have realistic expectations and discuss all potential risks and benefits with your healthcare team.

DBS is typically recommended for people with advanced Parkinson’s disease who experience:

  • Motor fluctuations and difficulty in maintaining consistent symptom control with medication.
  • Medication-induced dyskinesias, or involuntary movements caused by long-term use of Parkinson’s medications.
  • Severe tremors that are not adequately controlled by medication.
  • DBS is a surgery shown to increase the quality of life in patients with advanced Parkinson’s disease that results in large motor fluctuations, severe tremor and dyskinesias not controlled by medications. (1)
  • The most common side-effect of DBS is dysarthria (speech changes) regardless of electrode placement. (2)
  • DBS for PD remains an efficient symptomatic treatment, although the magnitude of improvement tends to decline over time. (2)

How do I access DBS?

Your neurologist will usually bring DBS up if they think it might help you. However, there is a stringent testing process to determine if you would be suitable for the operation. It’s advisable to explore all available options and optimise your medications to alleviate your most bothersome symptoms before opting for surgery.

How to get DBS

  1. Consultation: Start by discussing DBS with your neurologist. They will evaluate your symptoms, medical history, and overall health to determine if you’re a suitable candidate.
  2. Referral: If your neurologist thinks DBS is a good option, they will refer you to a specialised DBS centre.
  3. Evaluation: At the DBS centre, you’ll undergo a series of tests, including brain imaging (MRI or CT scans) and possibly recordings of brain cell activity.
  4. Surgery: The DBS surgery involves two main steps:
  5. Electrode Placement: Electrodes are implanted in the brain using MRI or CT guidance.
  6. Implanting the Pulse Generator: A few weeks later, a device similar to a heart pacemaker is implanted under the skin in the chest or abdomen.
  7. Programming: After the surgery, a neurologist will program the device to deliver the right amount of electrical stimulation.

Testing if DBS Would Work for You
Before the surgery, your neurologist will conduct a trial stimulation to see how your symptoms respond to the electrical impulses. This involves temporarily placing the electrodes and testing different stimulation settings.

The Process

  • Pre-Operative Evaluation: Includes medical history review, physical examination, and brain imaging.
  • Surgery: Electrodes are implanted in the brain, followed by implanting the pulse generator.
  • Post-Operative Care: Includes regular follow-up appointments to adjust the device settings and monitor your progress.
  • Lifestyle Adjustments: You’ll learn how to use a handheld controller to manage the device and check battery life.

A Decision Aid For Deep Brain Stimulation (DBS) Surgery

Michelle Fullard, MD, MSCE, and her team at UC Health Anschutz Medical Campus in Colorado have developed an interactive, online decision aid to help guide patients through the Deep Brain Stimulation (DBS) process. This resource walks patients through multiple aspects of the DBS journey, including:

1. Weighing the Potential Risks and Benefits: Understanding the potential advantages and drawbacks of DBS.
2. Understanding the Surgery: Detailed information on how the surgery is performed.
3. Recovery Process: What to expect during the recovery period.

This online decision aid is designed to provide patients with comprehensive information to make informed decisions about DBS, ensuring they are well-prepared for each stage of the process. (© 2024 University of Colorado Denver – Anschutz | Department of Neurology)

n.b. Parkinson’s Australia does not take responsibility for any third-party information and this is used to guide you in consultation with your neurologist.

Infosheet under review

For help with your device, contact your device manufacturer:

References:

(1) Rajamani, N., Friedrich, H., Butenko, K. et al. Deep brain stimulation of symptom-specific networks in Parkinson’s disease. Nat Commun 15, 4662 (2024). https://doi.org/10.1038/s41467-024-48731-1

(2) Hariz, M., & Blomstedt, P. (2022). Deep brain stimulation for Parkinson’s disease. Journal of internal medicine, 292(5), 764–778. https://doi.org/10.1111/joim.13541