Peripheral neuropathy in Parkinson’s refers to damage or dysfunction of the peripheral nerves. The changes to the nerves outside the brain and spinal cord can lead to various symptoms, including numbness, tingling, burning sensations, and weakness in the hands, feet, arms, or legs. In Parkinson’s, peripheral neuropathy may relate to factors such as aging, diabetes (which is more prevalent in people with Parkinson’s), or side effects of medications used to treat Parkinson’s.